研究業績

2024年

論文

• "Metabolic RNA Labeling and Translating Ribosome Affinity Purification for Measurement of Nascent RNA Translation"
  Hirotatsu Imai, Akio Yamashita
  Bio-protocol 14, 20, e5091 (2024).

  • DOI: 10.21769/BioProtoc.5091
• "Maintenance of R-loop structures by phosphorylated hTERT preserves genome integrity"
  Mitsuhiro Machitani, Akira Nomura, Taro Yamashita, Mami Yasukawa, Saori Ueki, Ken-Ichi Fujita, Toshihide Ueno, Akio Yamashita, Yoshikazu Tanzawa, Masahiko Watanabe, Toshiyasu Taniguchi, Noriko Saitoh, Shuichi Kaneko, Yukinari Kato, Hiroyuki Mano, Kenkichi Masutomi
  Nature Cell Biology 26, 6, 932-945 (2024).

  • URL
  • DOI: 10.1038/s41556-024-01427-6

2023年

論文

• "miR-125a-5p/miR-125b-5p contributes to pathological activation of angiotensin II-AT1R in mouse distal convoluted tubule cells by the suppression of Atrap"
  Keigo Hirota, Akio Yamashita, Eriko Abe, Takahiro Yamaji, Kengo Azushima, Shohei Tanaka, Shinya Taguchi, Shunichiro Tsukamoto, Hiromichi Wakui, Kouichi Tamura
  Journal of Biological Chemistry 299, 12, 105478 (2023).

  • DOI: 10.1016/j.jbc.2023.105478
• "Angiotensin II type 1 receptor-associated protein deletion combined with angiotensin II stimulation accelerates the development of diabetic kidney disease in mice on a C57BL/6 strain"
  Shinya Taguchi, Kengo Azushima, Takahiro Yamaji, Toru Suzuki, Eriko Abe, Shohei Tanaka, Keigo Hirota, Shunichiro Tsukamoto, Ryutaro Morita, Ryu Kobayashi, Sho Kinguchi, Akio Yamashita, Hiromichi Wakui & Kouichi Tamura
  Hypertension Research 47, 55–66 (2023).

  • DOI: 10.1038/s41440-023-01496-4
• "Angiotensin II type 1 receptor-associated protein in immune cells: a possible key factor in the pathogenesis of visceral obesity"
  Shunichiro Tsukamoto, Toru Suzuki, Hiromichi Wakui, Tatsuki Uehara, Juri Ichikawa, Hiroshi Okuda, Kotaro Haruhara, Kengo Azushima, Eriko Abe, Shohei Tanaka, Shinya Taguchi, Keigo Hirota, Sho Kinguchi, Akio Yamashita, Tomohiko Tamura, Kouichi Tamura
  Metabolism 149, December, 155706 (2023).

  • URL
  • DOI: 10.1016/j.metabol.2023.155706
• "Combination of sacubitril/valsartan and blockade of the PI3K pathway enhanced kidney protection in a mouse model of cardiorenal syndrome"
  Shunichiro Tsukamoto, Hiromichi Wakui, Tatsuki Uehara, Yuka Shiba, Kengo Azushima, Eriko Abe, Shohei Tanaka, Shinya Taguchi, Keigo Hirota, Shingo Urate, Toru Suzuki, Takayuki Yamada, Sho Kinguchi, Akio Yamashita, Kouichi Tamura
  European Heart Journal Open 3, 6, oead098 (2023).

  • URL
  • DOI: 10.1093/ehjopen/oead098
• "Simultaneous measurement of nascent transcriptome and translatome using 4-thiouridine metabolic RNA labeling and translating ribosome affinity purification"
  Imai H, Utsumi D, Hidetsugu T, Takahashi K, Kuroyanagi H, Yamashita A
  Nucleic Acids Research 51, 11, e76 (2023).

  • URL
  • DOI: 10.1093/nar/gkad545
• "An atlas of substrate specificities for the human serine/threonine kinome"
  Jared L. Johnson, Tomer M. Yaron, Emily M. Huntsman, Alexander Kerelsky, Junho Song, Amit Regev, Ting-Yu Lin, Katarina Liberatore, Daniel M. Cizin, Benjamin M. Cohen, Neil Vasan, Yilun Ma, Konstantin Krismer, Jaylissa Torres Robles, Bert van de Kooij, Anne E. van Vlimmeren, Nicole Andrée-Busch, Norbert F. Käufer, Maxim V. Dorovkov, Alexey G. Ryazanov, Yuichiro Takagi, Edward R. Kastenhuber, Marcus D. Goncalves, Benjamin D. Hopkins, Olivier Elemento, Dylan J. Taatjes, Alexandre Maucuer, Akio Yamashita, Alexei Degterev, Mohamed Uduman, Jingyi Lu, Sean D. Landry, Bin Zhang, Ian Cossentino, Rune Linding, John Blenis, Peter V. Hornbeck, Benjamin E. Turk, Michael B. Yaffe & Lewis C. Cantley
  Nature 613, 759–766 (2023).

  • URL
  • DOI: 10.1038/s41586-022-05575-3

2022年

論文

• "Angiotensin II type-1 receptor-associated protein interacts with transferrin receptor-1 and promotes its internalization"
  Eriko Abe, Akio Yamashita, Keigo Hirota, Takahiro Yamaji, Kengo Azushima, Shingo Urate, Toru Suzuki, Shohei Tanaka, Shinya Taguchi, Shunichiro Tsukamoto, Tatsuki Uehara, Hiromichi Wakui, Kouichi Tamura & Hidehisa Takahashi
  Scientific Reports 12, 17376 (2022).

  • URL
  • DOI: 10.1038/s41598-022-22343-5
• "Deficiency of the kidney tubular angiotensin II type1 receptor-associated protein ATRAP exacerbates streptozotocin-induced diabetic glomerular injury via reducing protective macrophage polarization"
  Haruhara K, Suzuki T, Wakui H, Azushima K, Kurotaki D, Kawase W, Uneda K, Kobayashi R, Ohki K, Kinguchi S, Yamaji T, Kato I, Ohashi K, Yamashita A, Tamura T, Tsuboi N, Yokoo T, Tamura K.
  Kidney International S0085-2538, 22, 00161-2 (2022).

  • URL
  • DOI: 10.1016/j.kint.2022.01.031
• "The flexible N-terminal motif of uL11 unique to eukaryotic ribosomes interacts with P-complex and facilitates protein translation"
  Yang L, Lee KM, Yu CWH, Imai H, Choi AKH, Banfield DK, Ito K, Uchiumi T, Wong KB
  Nucleic Acids Research 50, 5335–5348 (2022).

  • DOI: 10.1093/nar/gkac292

2021年

論文

• "Effects of tumor necrosis factor-α inhibition on kidney fibrosis and inflammation in a mouse model of aristolochic acid nephropathy"
  Taguchi S, Azushima K, Yamaji T, Urate S, Suzuki T, Abe E, Tanaka S, Tsukamoto S, Kamimura D, Kinguchi S, Yamashita A, Wakui H, Tamura K.
  Scientific Reports 11, 1, 23587 (2021).

  • URL
  • DOI: 10.1038/s41598-021-02864-1.
• "Distinct RNA polymerase transcripts direct the assembly of phase-separated DBC1 nuclear bodies in different cell lines"
  Taro Mannena, Masato Gotoa, Takuya Yoshizawaa, Akio Yamashitab, Tetsuro Hirosec, Toshiya Hayanoa
  Molecular Biology of the Cell 32, 21, ar33 (2021).

  • DOI: mbc.E21-02-0081
• "De novo ATP1A3 variants cause polymicrogyria"
  Miyatake, Satoko; Kato, Mitsuhiro; Kumamoto, Takuma; Hirose, Tomonori; Koshimizu, Eriko; Matsui, Takaaki; Takeuchi, Hideyuki; Doi, Hiroshi; Hamada, Keisuke; Nakashima, Mitsuko;
  Science Advances 7, 13, eabd2368 (2021).
• "Resistance to Tubulointerstitial Injury in a Mouse Remnant Kidney Model"
  Tanaka, Shohei; Wakui, Hiromichi; Azushima, Kengo; Tsukamoto, Shunichiro; Yamaji, Takahiro; Urate, Shingo; Suzuki, Toru; Abe, Eriko; Taguchi, Shinya; Yamada, Takayuki;
  (2021).
• "New vaccine production platforms used in developing SARS-CoV-2 vaccine candidates"
  Ura, Takehiro; Yamashita, Akio; Mizuki, Nobuhisa; Okuda, Kenji; Shimada, Masaru;
  Vaccine 39, 2, 197 (2021).
• "Potent mouse monoclonal antibodies that block SARS-CoV-2 infection"
  Guo, Youjia; Kawaguchi, Atsushi; Takeshita, Masaru; Sekiya, Takeshi; Hirohama, Mikako; Yamashita, Akio; Siomi, Haruhiko; Murano, Kensaku;
  Journal of Biological Chemistry 296, 100346 (2021).

2020年

論文

• "Direct visualization of translational GTPase factor pool formed around the archaeal ribosomal P-stalk by high-speed AFM"
  Imai H, Uchiumi T, Kodera N
  Proceedings of the National Academy of Sciences 117, 32386-32394 (2020).

  • DOI: 10.1073/pnas.2018975117
• "Arabidopsis ROOT PHOTOTROPISM2 Is a Light-Dependent Dynamic Modulator of Phototropin1"
  Kimura T, Tsuchida-Mayama T, Imai H, Okajima K, Ito K, Sakai T
  The Plant Cell 32, 2004-2019 (2020).

  • DOI: 10.1105/tpc.19.00926
• "The human papillomavirus E6 protein targets apoptosis-inducing factor (AIF) for degradation"
  Shimada, Masaru; Yamashita, Akio; Saito, Manami; Ichino, Motohide; Kinjo, Takao; Mizuki, Nobuhisa; Klinman, Dennis M; Okuda, Kenji;
  Scientific reports 10, 1, 1-14 (2020).
• "Shank2 Binds to aPKC and Controls Tight Junction Formation with Rap1 Signaling during Establishment of Epithelial Cell Polarity"
  Sasaki, Kazunori; Kojitani, Noriko; Hirose, Hiroko; Yoshihama, Yohei; Suzuki, Hidefumi; Shimada, Miho; Takayanagi, Ayumi; Yamashita, Akio; Nakaya, Masa-aki; Hirano, Hisashi;
  Cell reports 31, 1, 107407 (2020).
• "Effects of Rikkunshito treatment on renal fibrosis/inflammation and body weight reduction in a unilateral ureteral obstruction model in mice"
  Wakui, Hiromichi; Yamaji, Takahiro; Azushima, Kengo; Uneda, Kazushi; Haruhara, Kotaro; Nakamura, Akiko; Ohki, Kohji; Kinguchi, Sho; Kobayashi, Ryu; Urate, Shingo;
  Scientific reports 10, 1, 1-11 (2020).

2019年

論文

• "Angiotensin II type 1 receptor-associated protein deficiency attenuates sirtuin1 expression in an immortalised human renal proximal tubule cell line"
  Yamaji, Takahiro; Yamashita, Akio; Wakui, Hiromichi; Azushima, Kengo; Uneda, Kazushi; Fujikawa, Yumiko; Haku, Sona; Kobayashi, Ryu; Ohki, Kohji; Haruhara, Kotaro;
  Scientific reports 9, 1, 1-11 (2019).
• "Environmental stresses suppress nonsense-mediated mRNA decay (NMD) and affect cells by stabilizing NMD-targeted gene expression"
  Usuki, Fusako; Yamashita, Akio; Fujimura, Masatake;
  Scientific reports 9, 1, 1-15 (2019).
• "Effects of ATRAP in Renal Proximal Tubules on Angiotensin‐Dependent Hypertension"
  Kinguchi, Sho; Wakui, Hiromichi; Azushima, Kengo; Haruhara, Kotaro; Koguchi, Tomoyuki; Ohki, Kohji; Uneda, Kazushi; Matsuda, Miyuki; Haku, Sona; Yamaji, Takahiro;
  Journal of the American Heart Association 8, 8, e012395 (2019).
• "Effects of rikkunshito on renal fibrosis and inflammation in angiotensin II-infused mice"
  Azushima, Kengo; Uneda, Kazushi; Wakui, Hiromichi; Ohki, Kohji; Haruhara, Kotaro; Kobayashi, Ryu; Haku, Sona; Kinguchi, Sho; Yamaji, Takahiro; Minegishi, Shintaro;
  Scientific reports 9, 1, 1-10 (2019).
• "Functional Role of ATRAP, a Novel Receptor Binding Protein, in the Regulation of Renal Sodium Handling and Blood Pressure"
  TAMURA, Kouichi; UNEDA, Kazushi; KOBAYASHI, Ryu; AZUSHIMA, Kengo; OHSAWA, Masato; MASUDA, Shin-ichiro; HAKU, Sona; OHKI, Kohji; HARUHARA, Kotaro; KINGUCHI, Sho;
  Bulletin of the Society of Sea Water Science, Japan 73, 2, 54-58 (2019).
• "Translation-dependent unwinding of stem_loops by UPF1 licenses Regnase-1 to degrade inflammatory mRNAs"
  Mino, Takashi; Iwai, Noriki; Endo, Masayuki; Inoue, Kentaro; Akaki, Kotaro; Hia, Fabian; Uehata, Takuya; Emura, Tomoko; Hidaka, Kumi; Suzuki, Yutaka;
  Nucleic acids research 47, 16, 8838-8859 (2019).
• "A Receptor-Binding Molecule-Mediated Protective Tubular-Glomerular Interaction Against Diabetic Nephropathy by Promoting Tissue-Reparative Macrophage Polarization"
  Haruhara, Kotaro; Wakui, Hiromichi; Azushima, Kengo; Kurotaki, Daisuke; Kawase, Wataru; Uneda, Kazushi; Kobayashi, Ryu; Ohki, Kohji; Kinguchi, Sho; Yamaji, Takahiro;
  (2019).
• "Switch of the interactions between the ribosomal stalk and EF1A in the GTP-and GDP-bound conformations"
  Maruyama K, Imai H, Kawamura M, Ishino S, Ishino Y, Ito K, Uchiumi T
  Scientific reports 9, 14761 (2019).

  • DOI: 10.1038/s41598-019-51266-x
• "N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation"
  Yamasoba, Daichi; Sato, Kei; Ichinose, Takuya; Imamura, Tomoko; Koepke, Lennart; Joas, Simone; Reith, Elisabeth; Hotter, Dominik; Misawa, Naoko; Akaki, Kotaro;
  Nature microbiology 4, 9, 1532-1544 (2019).

2018年

論文

• "The ribosomal stalk protein is crucial for the action of the conserved ATPase ABCE1"
  Imai H, Abe T, Miyoshi T, Nishikawa S, Ito K, Uchiumi T
  Nucleic acids research 46, 7820-7830 (2018).

  • DOI: 10.1093/nar/gky619
• "Serine/Threonine-Protein Kinase SMG1"
  Akio Yamashita
  Encyclopedia of Signaling Molecules, 4885-4893 (2018).
• "Early enhanced leucine-rich α-2-glycoprotein-1 expression in glomerular endothelial cells of type 2 diabetic nephropathy model mice"
  Wakui, Hiromichi; Azushima, Kengo; Haruhara, Kotaro; Kinguchi, Sho; Ohki, Kohji; Uneda, Kazushi; Kobayashi, Ryu; Matsuda, Miyuki; Yamaji, Takahiro; Yamada, Takayuki;
  BioMed research international 2018 (2018).
• "Angiotensin II type 1 receptor-associated protein inhibits angiotensin II-induced insulin resistance with suppression of oxidative stress in skeletal muscle tissue"
  Ohki, Kohji; Wakui, Hiromichi; Kishio, Nozomu; Azushima, Kengo; Uneda, Kazushi; Haku, Sona; Kobayashi, Ryu; Haruhara, Kotaro; Kinguchi, Sho; Yamaji, Takahiro;
  Scientific reports 8, 1, 1-12 (2018).

2017年

論文

• "Adipocyte‐specific enhancement of angiotensin II type 1 receptor‐associated protein ameliorates diet‐induced visceral obesity and insulin resistance"
  Azushima, Kengo; Ohki, Kohji; Wakui, Hiromichi; Uneda, Kazushi; Haku, Sona; Kobayashi, Ryu; Haruhara, Kotaro; Kinguchi, Sho; Matsuda, Miyuki; Maeda, Akinobu;
  Journal of the American Heart Association 6, 3, e004488 (2017).
• "An angiotensin II type 1 receptor binding molecule has a critical role in hypertension in a chronic kidney disease model"
  Kobayashi, Ryu; Wakui, Hiromichi; Azushima, Kengo; Uneda, Kazushi; Haku, Sona; Ohki, Kohji; Haruhara, Kotaro; Kinguchi, Sho; Matsuda, Miyuki; Ohsawa, Masato;
  Kidney international 91, 5, 1115-1125 (2017).
• "Translational control of mRNAs by 3′-Untranslated region binding proteins"
  Yamashita, Akio; Takeuchi, Osamu;
  BMB reports 50, 4, 194 (2017).
• "Angiotensin II Type 1 receptor‐associated protein regulates kidney aging and lifespan independent of angiotensin"
  Uneda, Kazushi; Wakui, Hiromichi; Maeda, Akinobu; Azushima, Kengo; Kobayashi, Ryu; Haku, Sona; Ohki, Kohji; Haruhara, Kotaro; Kinguchi, Sho; Matsuda, Miyuki;
  Journal of the American Heart Association 6, 8, e006120 (2017).
• "Endoplasmic reticulum stress preconditioning modifies intracellular mercury content by upregulating membrane transporters"
  Usuki, Fusako; Fujimura, Masatake; Yamashita, Akio;
  Scientific reports 7, 1, 1-14 (2017).
• "Binding of translation elongation factors to individual copies of the archaeal ribosomal stalk protein aP1 assembled onto aP0"
  Honda T, Imai H, Suzuki, T, Miyoshi T, Ito, K, Uchiumi T
  Biochemical and biophysical research communications 483, 153-158 (2017).

  • DOI: 10.1016/j.bbrc.2016.12.175

2016年

論文

• "Human nonsense-mediated mRNA decay factor UPF2 interacts directly with eRF3 and the SURF complex"
  Lopez-Perrote, Andres; Castano, Raquel; Melero, Roberto; Zamarro, Teresa; Kurosawa, Hitomi; Ohnishi, Tetsuo; Uchiyama, Akiko; Aoyagi, Kyoko; Buchwald, Gretel; Kataoka, Naoyuki;
  Nucleic acids research 44, 4, 1909-1923 (2016).
• "The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation"
  Melero, Roberto; Hug, Nele; L_pez-Perrote, Andr_s; Yamashita, Akio; C_ceres, Javier F; Llorca, Oscar;
  Nature communications 7, 1, 1-12 (2016).

2015年

論文

• "Functional role of the C‐terminal tail of the archaeal ribosomal stalk in recruitment of two elongation factors to the sarcin/ricin loop of 23S rRNA"
  Imai H, Miyoshi T, Murakami R, Ito K, Ishino Y, Uchiumi T
  Genes to Cells 20, 613-624 (2015).

  • DOI: 10.1111/gtc.12256
• "Renal Tubule Angiotensin II Type 1 Receptor_Associated Protein Promotes Natriuresis and Inhibits Salt‐Sensitive Blood Pressure Elevation"
  Wakui, Hiromichi; Uneda, Kazushi; Tamura, Kouichi; Ohsawa, Masato; Azushima, Kengo; Kobayashi, Ryu; Ohki, Kohji; Dejima, Toru; Kanaoka, Tomohiko; Tsurumi‐Ikeya, Yuko;
  Journal of the american heart association 4, 3, e001594 (2015).
• "Mutations in the glutaminyl-tRNA synthetase gene cause early-onset epileptic encephalopathy"
  Kodera, Hirofumi; Osaka, Hitoshi; Iai, Mizue; Aida, Noriko; Yamashita, Akio; Tsurusaki, Yoshinori; Nakashima, Mitsuko; Miyake, Noriko; Saitsu, Hirotomo; Matsumoto, Naomichi;
  Journal of human genetics 60, 2, 97-101 (2015).
• "Angiotensin II type 1 receptor binding molecule ATRAP as a possible modulator of renal sodium handling and blood pressure in pathophysiology"
  Tamura, K; Wakui, H; Azushima, K; Uneda, K; Haku, S; Kobayashi, R; Ohki, K; Haruhara, K; Kinguchi, S; Matsuda, M;
  Current medicinal chemistry 22, 28, 3210-3216 (2015).

2014年

論文

• "aPKCλ maintains the integrity of the glomerular slit diaphragm through trafficking of nephrin to the cell surface"
  Satoh, Daisuke; Hirose, Tomonori; Harita, Yutaka; Daimon, Chikara; Harada, Tomonori; Kurihara, Hidetake; Yamashita, Akio; Ohno, Shigeo;
  The Journal of Biochemistry 156, 2, 115-128 (2014).
• "A hemizygous GYG2 mutation and Leigh syndrome: a possible link?"
  Imagawa, Eri; Osaka, Hitoshi; Yamashita, Akio; Shiina, Masaaki; Takahashi, Eihiko; Sugie, Hideo; Nakashima, Mitsuko; Tsurusaki, Yoshinori; Saitsu, Hirotomo; Ogata, Kazuhiro;
  Human genetics 133, 2, 225-234 (2014).
• "Structures of SMG1-UPFs complexes: SMG1 contributes to regulate UPF2-dependent activation of UPF1 in NMD"
  Melero, Roberto; Uchiyama, Akiko; Casta_o, Raquel; Kataoka, Naoyuki; Kurosawa, Hitomi; Ohno, Shigeo; Yamashita, Akio; Llorca, Oscar;
  Structure 22, 8, 1105-1119 (2014).
• "Deletion of the angiotensin II type 1 receptor_associated protein enhances renal sodium reabsorption and exacerbates angiotensin II_mediated hypertension"
  Ohsawa, Masato; Tamura, Kouichi; Wakui, Hiromichi; Maeda, Akinobu; Dejima, Toru; Kanaoka, Tomohiko; Azushima, Kengo; Uneda, Kazushi; Tsurumi-Ikeya, Yuko; Kobayashi, Ryu;
  Kidney international 86, 3, 570-581 (2014).
• "Effects of the angiotensin receptor blocker olmesartan on adipocyte hypertrophy and function in mice with metabolic disorders"
  Maeda, Akinobu; Tamura, Kouichi; Wakui, Hiromichi; Ohsawa, Masato; Azushima, Kengo; Uneda, Kazushi; Kanaoka, Tomohiko; Kobayashi, Ryu; Ohki, Kohji; Matsuda, Miyuki;
  BioMed research international 2014 (2014).
• "A novel phosphorylation-independent interaction between SMG6 and UPF1 is essential for human NMD"
  Nicholson, Pamela; Josi, Christoph; Kurosawa, Hitomi; Yamashita, Akio; M_hlemann, Oliver;
  Nucleic acids research 42, 14, 9217-9235 (2014).

2013年

論文

• "Upstream stimulatory factors 1 and 2 mediate the transcription of angiotensin II binding and inhibitory protein"
  Matsuda, Miyuki; Tamura, Kouichi; Wakui, Hiromichi; Maeda, Akinobu; Ohsawa, Masato; Kanaoka, Tomohiko; Azushima, Kengo; Uneda, Kazushi; Haku, Sona; Tsurumi-Ikeya, Yuko;
  Journal of Biological Chemistry 288, 26, 19238-19249 (2013).
• "Angiotensin receptor_binding protein ATRAP/Agtrap inhibits metabolic dysfunction with visceral obesity"
  Maeda, Akinobu; Tamura, Kouichi; Wakui, Hiromichi; Dejima, Toru; Ohsawa, Masato; Azushima, Kengo; Kanaoka, Tomohiko; Uneda, Kazushi; Matsuda, Miyuki; Yamashita, Akio;
  Journal of the American Heart Association 2, 4, e000312 (2013).
• "The novel PAR-1-binding protein MTCL1 has crucial roles in organizing microtubules in polarizing epithelial cells"
  Sato, Yoshinori; Akitsu, Masashi; Amano, Yoshiko; Yamashita, Kazunari; Ide, Mariko; Shimada, Kyoko; Yamashita, Akio; Hirano, Hisashi; Arakawa, Noriaki; Maki, Takahisa;
  Journal of cell science 126, 20, 4671-4683 (2013).
• "Role of SMG‐1‐mediated U pf1 phosphorylation in mammalian nonsense‐mediated m RNA decay"
  Yamashita, Akio;
  Genes to Cells 18, 3, 161-175 (2013).
• "Bofu-tsu-shosan, an oriental herbal medicine, exerts a combinatorial favorable metabolic modulation including antihypertensive effect on a mouse model of human metabolic disorders with visceral obesity"
  Azushima, Kengo; Tamura, Kouichi; Wakui, Hiromichi; Maeda, Akinobu; Ohsawa, Masato; Uneda, Kazushi; Kobayashi, Ryu; Kanaoka, Tomohiko; Dejima, Toru; Fujikawa, Tetsuya;
  PLoS One 8, 10, e75560 (2013).
• "Nonsense-mediated mRNA decay―mechanisms of substrate mRNA recognition and degradation in mammalian cells"
  Schweingruber, Christoph; Rufener, Simone C; Z_nd, David; Yamashita, Akio; M_hlemann, Oliver;
  Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms 1829, 6-7, 612-623 (2013).
• "Endoplasmic reticulum stress preconditioning attenuates methylmercury-induced cellular damage by inducing favorable stress responses"
  Usuki, Fusako; Fujimura, Masatake; Yamashita, Akio;
  Scientific reports 3, 1, 1-10 (2013).
• "The physiology and pathophysiology of a novel angiotensin receptor-binding protein ATRAP/Agtrap"
  Tamura, Kouichi; Wakui, Hiromichi; Maeda, Akinobu; Dejima, Toru; Ohsawa, Masato; Azushima, Kengo; Kanaoka, Tomohiko; Haku, Sona; Uneda, Kazushi; Masuda, Shin-ichiro;
  Current pharmaceutical design 19, 17, 3043-3048 (2013).
• "Inhibition of SMG-8, a subunit of SMG-1 kinase, ameliorates nonsense-mediated mRNA decay-exacerbated mutant phenotypes without cytotoxicity"
  Usuki, Fusako; Yamashita, Akio; Shiraishi, Tadafumi; Shiga, Atsushi; Onodera, Osamu; Higuchi, Itsuro; Ohno, Shigeo;
  Proceedings of the National Academy of Sciences 110, 37, 15037-15042 (2013).
• "Activation of angiotensin II type 1 receptor-associated protein exerts an inhibitory effect on vascular hypertrophy and oxidative stress in angiotensin II-mediated hypertension"
  Wakui, Hiromichi; Dejima, Toru; Tamura, Kouichi; Uneda, Kazushi; Azuma, Koichi; Maeda, Akinobu; Ohsawa, Masato; Kanaoka, Tomohiko; Azushima, Kengo; Kobayashi, Ryu;
  Cardiovascular Research 100, 3, 511-519 (2013).
• "Enhanced angiotensin receptor-associated protein in renal tubule suppresses angiotensin-dependent hypertension"
  Wakui, Hiromichi; Tamura, Kouichi; Masuda, Shin-ichiro; Tsurumi-Ikeya, Yuko; Fujita, Megumi; Maeda, Akinobu; Ohsawa, Masato; Azushima, Kengo; Uneda, Kazushi; Matsuda, Miyuki;
  Hypertension 61, 6, 1203-1210 (2013).

2012年

論文

• "Integrated regulation of PIKK-mediated stress responses by AAA+ proteins RUVBL1 and RUVBL2"
  Izumi, Natsuko; Yamashita, Akio; Ohno, Shigeo;
  Nucleus 3, 1, 29-43 (2012).
• "Heat shock protein 90 regulates phosphatidylinositol 3‐kinase‐related protein kinase family proteins together with the RUVBL1/2 and Tel2‐containing co‐factor complex"
  Izumi, Natsuko; Yamashita, Akio; Hirano, Hisashi; Ohno, Shigeo;
  Cancer science 103, 1, 50-57 (2012).
• "Analysis of interferon-beta mRNA stability control after poly (I: C) stimulation using RNA metabolic labeling by ethynyluridine"
  Abe, Kaito; Ishigami, Tomoaki; Shyu, Ann-Bin; Ohno, Shigeo; Umemura, Satoshi; Yamashita, Akio;
  Biochemical and biophysical research communications 428, 1, 44-49 (2012).
• "N-and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5: SMG-7 during NMD"
  Okada-Katsuhata, Yukiko; Yamashita, Akio; Kutsuzawa, Kei; Izumi, Natsuko; Hirahara, Fumiki; Ohno, Shigeo;
  Nucleic acids research 40, 3, 1251-1266 (2012).

2011年

論文

• "The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8"
  Arias-Palomo, Ernesto; Yamashita, Akio; Fern_ndez, Israel S; N__ez-Ram_rez, Rafael; Bamba, Yumi; Izumi, Natsuko; Ohno, Shigeo; Llorca, Oscar;
  Genes & development 25, 2, 153-164 (2011).
• "異常な mRNA を分解する仕組み (RNA の解析)--(病態疾患と動態解析)"
  山下暁朗;
  臨床検査 55, 9, 885-891 (2011).
• "Post-transcriptional defects of antioxidant selenoenzymes cause oxidative stress under methylmercury exposure"
  Usuki, Fusako; Yamashita, Akio; Fujimura, Masatake;
  Journal of Biological Chemistry 286, 8, 6641-6649 (2011).
• "Characterization of SMG-9, an essential component of the nonsense-mediated mRNA decay SMG1C complex"
  Fernandez, Israel S; Yamashita, Akio; Arias-Palomo, Ernesto; Bamba, Yumi; Bartolome, Ruben A; Canales, M Angeles; Teixid_, Joaqu_n; Ohno, Shigeo; Llorca, Oscar;
  Nucleic acids research 39, 1, 347-358 (2011).
• "A novel role for hSMG-1 in stress granule formation"
  Brown, James AL; Roberts, Tara L; Richards, Renee; Woods, Rick; Birrell, Geoff; Lim, Yi Chieh; Ohno, Shigeo; Yamashita, Akio; Abraham, Robert T; Gueven, Nuri;
  Molecular and cellular biology 31, 22, 4417-4429 (2011).
• "Mutations in POLR3A and POLR3B encoding RNA Polymerase III subunits cause an autosomal-recessive hypomyelinating leukoencephalopathy"
  Saitsu, Hirotomo; Osaka, Hitoshi; Sasaki, Masayuki; Takanashi, Jun-ichi; Hamada, Keisuke; Yamashita, Akio; Shibayama, Hidehiro; Shiina, Masaaki; Kondo, Yukiko; Nishiyama, Kiyomi;
  The American Journal of Human Genetics 89, 5, 644-651 (2011).

2010年

論文

• "Analysis of nonsense-mediated mRNA decay by monitoring mRNA half-lives in mammalian cells"
  Yamashita, Akio; Ohno, Shigeo;
  Cold Spring Harbor Protocols 2010, 2, pdb. prot5386 (2010).
• "AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay"
  Izumi, Natsuko; Yamashita, Akio; Iwamatsu, Akihiro; Kurata, Rie; Nakamura, Hiroki; Saari, Bonnie; Hirano, Hisashi; Anderson, Philip; Ohno, Shigeo;
  Science signaling 3, 116, ra27-ra27 (2010).
• "ASPP2 regulates epithelial cell polarity through the PAR complex"
  Cong, Weili; Hirose, Tomonori; Harita, Yutaka; Yamashita, Akio; Mizuno, Keiko; Hirano, Hisashi; Ohno, Shigeo;
  Current Biology 20, 15, 1408-1414 (2010).

2009年

論文

• "MRNA surveillance"
  Yamashita, Akio; Usuki, Fusako;
  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 54, 16 Suppl, 2219-2225 (2009).
• "SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay"
  Yamashita, Akio; Izumi, Natsuko; Kashima, Isao; Ohnishi, Tetsuo; Saari, Bonnie; Katsuhata, Yukiko; Muramatsu, Reiko; Morita, Tomoko; Iwamatsu, Akihiro; Hachiya, Takahisa;
  Genes & development 23, 9, 1091-1105 (2009).

2007年

論文

• "Human TOB, an antiproliferative transcription factor, is a poly (A)-binding protein-dependent positive regulator of cytoplasmic mRNA deadenylation"
  Ezzeddine, Nader; Chang, Tsung-Cheng; Zhu, Wenmiao; Yamashita, Akio; Chen, Chyi-Ying A; Zhong, Zhenping; Yamashita, Yukiko; Zheng, Dinghai; Shyu, Ann-Bin;
  Molecular and cellular biology 27, 22, 7791-7801 (2007).
• "Versatile applications of transcriptional pulsing to study mRNA turnover in mammalian cells"
  Chen, Chyi-Ying A; Yamashita, Yukiko; Chang, Tsung-Cheng; Yamashita, Akio; Zhu, Wenmiao; Zhong, Zhenping; Shyu, Ann-Bin;
  Rna 13, 10, 1775-1786 (2007).
• "Distant N-and C-terminal domains are required for intrinsic kinase activity of SMG-1, a critical component of nonsense-mediated mRNA decay"
  Morita, Tomoko; Yamashita, Akio; Kashima, Isao; Ogata, Kazuhiro; Ishiura, Shoichi; Ohno, Shigeo;
  Journal of Biological Chemistry 282, 11, 7799-7808 (2007).

2006年

論文

• "Specific inhibition of nonsense-mediated mRNA decay components, SMG-1 or Upf1, rescues the phenotype of Ullrich disease fibroblasts"
  Usuki, Fusako; Yamashita, Akio; Kashima, Isao; Higuchi, Itsuro; Osame, Mitsuhiro; Ohno, Shigeo;
  Molecular Therapy 14, 3, 351-360 (2006).
• "Binding of a novel SMG-1_Upf1_eRF1_eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay"
  Kashima, Isao; Yamashita, Akio; Izumi, Natsuko; Kataoka, Naoyuki; Morishita, Ryo; Hoshino, Shinichi; Ohno, Mutsuhito; Dreyfuss, Gideon; Ohno, Shigeo;
  Genes & development 20, 3, 355-367 (2006).
• "Role of SMG-1-mediated phosphorylation of Upf1 in NMD"
  Yamashita, Akio; Kashima, Isao; Ohno, Shigeo;
  Maquat LE. Georgetown, Texas: Landes Bioscience, 85-95 (2006).

2005年

論文

• "The role of SMG-1 in nonsense-mediated mRNA decay"
  Yamashita, Akio; Kashima, Isao; Ohno, Shigeo;
  Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1754, 1-2, 305-315 (2005).
• "Concerted action of poly (A) nucleases and decapping enzyme in mammalian mRNA turnover"
  Yamashita, Akio; Chang, Tsung-Cheng; Yamashita, Yukiko; Zhu, Wenmiao; Zhong, Zhenping; Chen, Chyi-Ying A; Shyu, Ann-Bin;
  Nature structural & molecular biology 12, 12, 1054-1063 (2005).
• "SMG-1 binding protein and screening method for substances that can regulate the activity thereof"
  Ohno, Shigeo; Ohnishi, Tetsuo; Yamashita, Akio;
  (2005).

2004年

論文

• "Inhibition of nonsense‐mediated mRNA decay rescues the phenotype in Ullrich's disease"
  Usuki, Fusako; Yamashita, Akio; Higuchi, Itsuro; Ohnishi, Tetsuo; Shiraishi, Tadafumi; Osame, Mitsuhiro; Ohno, Shigeo;
  Annals of Neurology: Official Journal of the American Neurological Association and the Child Neurology Society 55, 5, 740-744 (2004).
• "UNR, a new partner of poly (A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinant"
  Chang, Tsung-Cheng; Yamashita, Akio; Chen, Chyi-Ying A; Yamashita, Yukiko; Zhu, Wenmiao; Durdan, Simon; Kahvejian, Avak; Sonenberg, Nahum; Shyu, Ann-Bin;
  Genes & development 18, 16, 2010-2023 (2004).

2003年

論文

• "Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7"
  Ohnishi, Tetsuo; Yamashita, Akio; Kashima, Isao; Schell, Thomas; Anders, Kirk R; Grimson, Andrew; Hachiya, Takahisa; Hentze, Matthias W; Anderson, Philip; Ohno, Shigeo;
  Molecular cell 12, 5, 1187-1200 (2003).
• "Loss of von Hippel-Lindau protein causes cell density dependent deregulation of CyclinD1 expression through hypoxia-inducible factor"
  Baba, Masaya; Hirai, Syuiohi; Yamada-Okabe, Hisafumi; Hamada, Kenji; Tabuchi, Hisahiro; Kobayashi, Kazuki; Kondo, Keiichi; Yoshida, Minoru; Yamashita, Akio; Kishida, Takeshi;
  Oncogene 22, 18, 2728-2738 (2003).

2002年

論文

• "mRNA surveillance"
  Yamashita, Akio; Ohnishi, Tetsuo; Ohno, Shigeo;
  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 47, 2, 101-112 (2002).

2001年

論文

• "Cloning and characterization of the T‐box gene Tbx6 in Xenopus laevis"
  Uchiyama, Hideho; Kobayashi, Teruaki; Yamashita, Akio; Ohno, Shigeo; Yabe, Shigeharu;
  Development, growth & differentiation 43, 6, 657-669 (2001).
• "Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay"
  Yamashita, Akio; Ohnishi, Tetsuo; Kashima, Isao; Taya, Yoichi; Ohno, Shigeo;
  Genes & development 15, 17, 2215-2228 (2001).
• "PAR‐6 regulates aPKC activity in a novel way and mediates cell‐cell contact‐induced formation of the epithelial junctional complex"
  Yamanaka, Tomoyuki; Horikoshi, Yosuke; Suzuki, Atsushi; Sugiyama, Yuki; Kitamura, Koichi; Maniwa, Rika; Nagai, Yoko; Yamashita, Akio; Hirose, Tomonori; Ishikawa, Hiroko;
  Genes to Cells 6, 8, 721-731 (2001).

2000年

論文

• "MAPK upstream kinase (MUK)-binding inhibitory protein, a negative regulator of MUK/dual leucine zipper-bearing kinase/leucine zipper protein kinase"
  Fukuyama, Keiko; Yoshida, Michihiko; Yamashita, Akio; Deyama, Tetsuya; Baba, Masaya; Suzuki, Atsushi; Mohri, Hiroshi; Ikezawa, Zenro; Nakajima, Hiroshi; Hirai, Syu-ichi;
  Journal of Biological Chemistry 275, 28, 21247-21254 (2000).

1998年

論文

• "Differential activation of two JNK activators, MKK7 and SEK1, by MKN28-derived nonreceptor serine/threonine kinase/mixed lineage kinase 2"
  Hirai, Syu-ichi; Noda, Kumi; Moriguchi, Tetsuo; Nishida, Eisuke; Yamashita, Akio; Deyama, Tetsuya; Fukuyama, Keiko; Ohno, Shigeo;
  Journal of Biological Chemistry 273, 13, 7406-7412 (1998).

1997年

論文

• "Involvement of protein kinase C in the activation of extracellular signal-regulated kinase 1/2 by UVC irradiation"
  Zhuang, Shougang; Hirai, Syu-ichi; Mizuno, Keiko; Suzuki, Atsushi; Akimoto, Kazunori; Izumi, Yasushi; Yamashita, Akio; Ohno, Shigeo;
  Biochemical and biophysical research communications 240, 2, 273-278 (1997).